Table 1. Patient characteristics of the analysis population formed by PSM.

	ARMIN (N = 5033)	Controls(N = 10 039)	Total(N = 15 072)
Demographics
– male sex, N (%)	2231 (44.3)	4450 (44.3)	6681 (44.3)
– age in years, mean ± SD	72.6 ± 11.6	73.7 ± 11.4	73.4 ± 11.4
Selected comorbidities and clinical characteristics taken from inpatient and outpatient diagnoses in the year before the index date
Elixhauser comorbidity score (17), mean ± SD	6.3 ± 2.8	6.4 ± 3.0	6.4 ± 3.0
Utilization of the health care system (in the year before the index date)
Number of previous all-cause hospitalizations per patient
– Median (IQR)	0 (0, 1)	1 (0, 1)	1 (0, 1)
– Mean ± SD	0.7 ± 1.1	1.0 ± 1.5	0.9 ± 1.4
Number of previous specific* hospitalizations per patient
– Median (IQR)	0 (0, 0)	0 (0, 1)	0 (0, 0)
– Mean ± SD	0.3 ± 0.7	0.4 ± 0.9	0.4 ± 0.8
High utilization of outpatient healthcare services, N (%)	2151 (42.7)	4283 (42.7)	6434 (42.7)
Medication (in the year before the index date)
Number of different ATC codes per patient
– Median (IQR)	9 (7, 13)	9 (7, 13)	9 (7, 13)
– Mean ± SD	10.2 ± 4.4	10.0 ± 4.8	10.1 ± 4.7

* Specific hospitalizations were defined as admissions potentially related to adverse drug reactions to currently prescribed drugs, according to Meid et al. 2018 (15) ARMIN,Medicines Initiative Saxony-Thuringia; ATC, Anatomic Therapeutic Chemical classification system; IQR, interquartile range; N, number;

PSM, propensity score matching; SD, standard deviation