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. 2023 Jul 11;10:1204740. doi: 10.3389/fmolb.2023.1204740

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Copyright © 2023 Chen, Tang, Hou, Luo, Chen, Qiu, Chen, Li, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profiles of all detected tsRNAs sequencing data in PAH patients and healthy controls. (A) Expression heatmap of all detected tsRNAs. (B) Volcano maps of differentially expressed tsRNAs in PAH patients (Test) vs. healthy controls. The vertical dotted lines manifest 2.0-fold changes (log2 scaled) up and down, respectively, and the horizontal dotted line shows a p-value of 0.05 (-log10 scaled). The red and blue points denote the significantly different expressed tsRNAs. (C) Scatter plots between the two groups. The values of the X and Y-axes in the scatter plot are the averaged transcript per million values of each group (log2 scaled). tsRNAs above the top line (red dots, upregulation) or below the bottom line (blue dots, downregulation) indicate more than 1.5-fold change between two compared groups. Gray dots indicate non-differentially expressed tsRNAs.