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. 2023 Jul 11;10:1204740. doi: 10.3389/fmolb.2023.1204740

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Copyright © 2023 Chen, Tang, Hou, Luo, Chen, Qiu, Chen, Li, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction of signaling pathways of the eight validated tsRNAs. Analysis showed that the target genes of (A) the four upregulated tsRNAs and (B) the four downregulated tsRNAs’ biological function. KEGG analyses of pathways on upregulated tsRNAs (C) and downregulated tsRNAs (D). (E) Mapping of the TGF-β signaling pathway in upregulated tsRNAs. (F) Mapping of the cancer signaling pathway in downregulated tsRNAs. Yellow marked nodes are associated with downregulated genes, orange marked nodes are associated with upregulated or only whole dataset genes, green nodes have no significance.