. 2023 Jul 11;14:1184572. doi: 10.3389/fphar.2023.1184572

TABLE 4.

Polysaccharides from marine life and animal with antioxidation and anti-diabetic effects.

Polysaccharide source	Monosaccharides composition	Models	Administration	Mechanism	Positive control	Reference
Sargassum thunbergii	Ara: gal: glu: xyl:man:gal A: glu A = 1.94: 30.7: 4.54: 23.2: 17.6: 8.11:13.9	Insulin-resistant HepG2 cells	0.1, 0.5, and 1.0 mg/mL) for 24 h	↓: α-glucosidase; improving the glucose uptake in insulin-resistant		Ren et al. (2017)
Laminaria japonica		MIN6 cells exposed 125 mM H2O2 for 2 h	25, 50, 100, or 200 mg/mL	↓: ROS		Wu et al. (2022b)
Laminaria japonica		MIN6 cells exposed 125 mM H2O2 for 2 h	25, 50, 100, or 200 mg/mL	↑: SOD, SIRT1-PGC1-α pathway, Nrf2		Wu et al. (2022b)
Field cricket (Gryllus bimaculatus)	Rha: rib: ara: fru: glu = 81.10:7.16:5.91:1.91:1.62	Cg-m+/+Leprdb, heterozygous (db/+) and homozygotes (db/db)	5 mg/kg	↑: CAT, SOD and GSH-Px activities	metformin	Ahn et al. (2020)
Misgurnus anguillicaudatus (Cantor)	Gal:Fuc:man = 5:4:1	STZ induced diabetic mice	50, 100 and 200 mg/kg	↓: TNF-α, IL-6, MCP-1, and MDA	metformin	Zhou et al. (2015b)
Misgurnus anguillicaudatus (Cantor)	Gal:Fuc:man = 5:4:1	STZ induced diabetic mice	50, 100 and 200 mg/kg	↑: SOD and GPx	metformin	Zhou et al. (2015b)