Scheme 1. Synthetic Strategy to Prepare 2 and 4.
Reagents and conditions: (i) 2-bromoethoxy-tert-butyldimethylsilane, NaH, DMF, rt, 24 h; (ii) 2 M HCl, 100 °C, 2 h; (iii) NBS, MeCN/H2O, rt, 30 min; (iv) AcONa, AcOH, 130 °C, 7 h.
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