Scheme 1. Synthesis of 3′-O-Ψ-Loaded 5′-O-MIP-2′-deoxynucleosides.
Conditions: (i) 2,2-dimethoxypropane, THF, TsOH·H2O, at r.t. for 3 h; (ii) TBAF·3H2O, THF, at r.t. for 2 h—overnight; (iii) (−)-PSI/(+)-PSI, DBU, MeCN. at r.t. for 2 h.
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