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. 2023 Jul 11;88(14):9823–9834. doi: 10.1021/acs.joc.3c00467

Scheme 3. One-Pot Benzyl Deprotection with TFA.

Scheme 3

Reaction conditions of Step II: Ugi reaction crude (0.2–0.5 mmol), 0.1 M TFA, 80 °C, 12 h, conventional heating; ayields from the one-pot procedure without isolation of GBB intermediates; btotal yields calculated over the two-step procedure with isolated GBB intermediates; cyields from only the deprotection step II with purified GBB intermediates.