Scheme 3. One-Pot Benzyl Deprotection with TFA.
Reaction conditions of Step II: Ugi reaction crude (0.2–0.5 mmol), 0.1 M TFA, 80 °C, 12 h, conventional heating; ayields from the one-pot procedure without isolation of GBB intermediates; btotal yields calculated over the two-step procedure with isolated GBB intermediates; cyields from only the deprotection step II with purified GBB intermediates.