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UPLC-MS analyses of l-FDAA-derivatized in vitro GntC D2O assays identify the incorporation of up to three deuterium atoms in γ-hydroxy-l-arginine substrates. (A) Increase of +3 Da is observed in linear substrate 1 and cyclic product 2 (1-d3 and 2-d3, respectively) in the presence of D2O and GntC. (B) Substrate diastereomer 1′ also shows an increase of +3 Da (1′-d3) in the presence of D2O-buffered GntC despite any cyclic product formation.
