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. 2023 Jul 11;13:1161410. doi: 10.3389/fonc.2023.1161410

Figure 2.

Figure 2

FGF3 knockdown affected the proliferation and cell cycle in MA-891 and TA-1106 cells. (A) Comparison of the knockdown effects of siRNA-297, 380, and 465 on FGF3 in MA-891 (a) and TA-1106 (b) cells. (B) Absorbance measurements of siRNA-297 cells and siRNA-NC cells at 450 nm by the CCK8 assay. (C) A plate colony formation assay showed differences in colony formation ability between siRNA-297 and siRNA-NC from MA-891 (a) and TA-1106 (b), respectively. A histogram showing the quantitative results of the colony-forming ability of MA-891 and TA-1106 cells before and after treatment (c). (D) Flow cytometric analyses of cell cycles were performed on siRNA-297 (a) and siRNA-NC (b) from MA-891 and TA-1106 (c, d), respectively. The proportion of cells in G1 phase (e), S phase (f), and G2 phase (g) in each group was also quantitatively compared. Each bar represents the mean ± standard deviation of three independent experiments. Statistically significant differences are indicated as ***P <0.001; **P <0.01. FGF3, fibroblast growth factor 3; CCK8, cell viability cell counting Kit-8; TA2, Tientsin albino 2.