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. 2023 Jul 11;13:1161410. doi: 10.3389/fonc.2023.1161410

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Copyright © 2023 Chen, Zhang, Liu, Chen, Zheng, Zhu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF3 knockdown inhibited the migration and invasion abilities of MA-891 and TA-1106 cells. (A) Cell migration of siRNA-NC and siRNA-297 cells was assessed by a transwell assay (a). The quantitative analysis results of the transwell migration experiment in MA-891 (b) and TA-1106 (c) after transfection with siRNA-NC or siRNA-297. Each bar represents the mean ± standard deviation (SD) of three independent experiments. (B) The cell invasion ability of siRNA-NC and siRNA-297 cells was assessed by a matrigel-coated transwell assay (a). The quantitative analysis results of the transwell invasion experiment in MA-891 (b) and TA-1106 (c) after transfection with siRNA-NC or siRNA-297. (C) The scratch wound healing assay was used to assess the cell migration capacity of MA-891 (A) and TA-1106 cells (B) transfected with siRNA-NC or siRNA-297. A histogram showing the quantitative comparison of scratch wound healing assay results (c). (D) Comparison of expression levels of EMT markers between siRNA-297 and siRNA-NC cells by western blot analysis (a). Histograms showing the quantitative results of vimentin (b), N-cadherin (c), Twist (d), and E-cadherin (e) expression in MA-891 and TA-1106 cells transfected with siRNA-NC or siRNA-297. (E) Expression levels of N-cadherin in siRNA-NC-transfected MA-891 (a) and TA-1106 cells (b) were detected by ICC, as were the results of siRNA-297-transfected MA-891 (c) and TA-1106 cells (d). Statistically significant differences are indicated as ***P <0.001; **P <0.01; *P v0.05; and ns = not significant. FGF3, fibroblast growth factor 3; EMT, epithelial-mesenchymal transition; TA2, Tientsin albino; ICC, immunocytochemistry.