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The mean change of the (A) body weight, (B) food intake, and (C) caloric intake per week in the control, cafeteria diet (CAFD)-, flaxseed lignan extract (FLE)-, and FLE/F13A-treated rat groups over 12 weeks. F13A is an apelin-13 receptor blocker. Values are presented as the mean ± SD (n = 6 per group; repeated measures ANOVA followed by Tukey’s multiple comparison test; * p < 0.05, **** p < 0.0001).
