TABLE 2.
Effect of flaxseed lignan extract (FLE) on final body weight, food intake, serum lipid profile, and atherogenic indices in experimental rat groups.
| Control | FLE | CAFD | CAFD/FLE | CAFD/FLE/F13A | |
|---|---|---|---|---|---|
| Final body weight (g) | 297.2 ± 9.3 | 285.0 ± 9.1 | 387.4 ± 6.9**** | 341.8 ± 7.3#### | 367.5 ± 13.2@@@ |
| Food Intake (g/day) | 18.4 ± 1.2 | 17.9 ± 1.6 | 17.3 ± 1.1 | 16.9 ± 2.0 | 17.1 ± 1.5 |
| Serum TC (mg/dL) | 86.8 ± 8.6 | 84.6 ± 8.7 | 195.2 ± 7.7*** | 88.3 ± 6.4### | 180.1 ± 4.7@@@ |
| Serum TG (mg/dL) | 63.3 ± 6.2 | 60.2 ± 6.5 | 128.2 ± 6.3*** | 66.4 ± 6.7### | 77.6 ± 3.8@ |
| Serum LDL-C (mg/dL) | 32.1 ± 10.3 | 26.8 ± 11.6 | 148.9 ± 8*** | 33 ± 9.9### | 127.2 ± 3.5@@@ |
| Serum HDL-C (mg/dL) | 42.1 ± 6.5 | 45.8 ± 7 | 20.7 ± 4.2*** | 42 ± 7.6### | 34.6 ± 1.8 |
| Serum oxLDL (ng/mL) | 5.9 ± 0.6 | 5.6 ± 0.7 | 11.1 ± 0.9**** | 8.6 ± 1## | 10.4 ± 1.5@ |
| AI | 0.18 ± 0.07 | 0.12 ± 0.1 | 0.8 ± 0.1*** | 0.20 ± 0.09### | 0.35 ± 0.03@ |
| AC | 1.1 ± 0.36 | 0.9 ± 0.46 | 8.8 ± 2.2*** | 1.2 ± 0.49### | 4.2 ± 0.28@@@ |
| CRR | 2.1 ± 0.36 | 1.9 ± 0.46 | 9.8 ± 2.2*** | 2.2 ± 0.49### | 5.2 ± 0.28@@@ |
Data are presented as the mean ± SD (n = 6 per group); one-way ANOVA followed by Tukey’s multiple comparison test.
**p < 0.01, ***p < 0.001, vs. the control group.
### p < 0.001, vs. the CAFD-treated group.
@ p < 0.05, @@@ p < 0.001 vs. CAFD/FLE-treated group.
AC, atherogenic coefficient; AI, atherogenic index; CRR, cardiac risk ratio; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; oxLDL, oxidized low-density lipoprotein; TC, total cholesterol; TG, triglycerides.