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. 2023 Jul 11;14:1162520. doi: 10.3389/fphys.2023.1162520

FIGURE 4.

FIGURE 4

Individual ML-score for each patient with multiple LV pacing sites: clinical (reference) Ref-PS; optimal ML-PS, pacing at LV LAT area defined in baseline; pacing at the LV pacing site minimizing the total biventricular activation time—TAT-PS. Patients are sorted according to their ML-score at Ref-PS pacing. Following individual patient characteristics are shown below: a clinical responder (+) or non-responder (-), a positive (+)/negative (-) prediction of CRT response based on the ML-score value generated by the LR predictive model from the clinical data and simulations at Ref-PS and ML-PS, and a presence (+) of the combination of a positive ML-score at ML-PS and a low distance D PS < 30 mm from the Ref-PS to optimal ML. Bold red circles indicate patients with a positive prediction of CRT response at ML-PS for the clinical non-responders.