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. 2023 Jul 11;14:1162520. doi: 10.3389/fphys.2023.1162520

TABLE 1.

Statistics of simulated total activation time 95% (TAT95), QRSd, the ML-score and distance from LV pacing site to the scar area at baseline LBBB activation and BiV pacing at ref-PS and ML-PS in the total patient cohort and groups of responders and non-responders.

Simulated feature Total cohort (n = 57) Responders (n = 23) Non-responders (n = 34)
TAT95, ms LBBB 151 [137; 166] 153 [141; 164] 150 [133; 169]
ref-PS 99 [88; 111]* 96 [88; 106]* 102 [88; 112]*
ML-PS 100 [89; 114]* 99 [89; 113]* 102 [86; 114]*
QRSd, ms LBBB 190 [175; 205] 195 [180; 204] 189 [173; 210]
ref-PS 142 [132; 155]* 142 [132; 151]* 147 [131; 156]*
ML-PS 144 [132; 154]* 142 [136; 152]* 144 [129; 157]*
ML-score ref-PS 0.31 [0.14; 0.68] 0.73 [0.36; 0.95] 0.19 [0.07; 0.39]#
ML-PS 0.56 [0.33; 0.87]$ 0.82 [0.64; 0.98]$ 0.42 [0.20; 0.73]$, #
Scar-LVPS distance, mm ref-PS 34 [10; 49] 44 [19; 53] 25 [3; 43]#
ML-PS 58 [45; 71]$ 61 [51; 66]$ 55 [41; 72]$
D PS , mm ML-PS 50 [26; 78] 35 [21; 61] 64 [41; 92]#

Median [25th percentile; 75th percentile]. * - p < 0.05, * - p < 0.01 ML-PS vs. LBBB. $ - p < 0.05, $ - p < 0.01 ML-PS vs. ref-PS. Comparison of dependent groups was performed using Friedman’s test, followed by a pairwise comparison adjusted for multiple comparisons. # - p < 0.05, # - p < 0.01 Responders vs. Non-responders. Comparison between two independent groups was carried out using Mann-Whitney test.