FIG. 1.

Cumulative incidence of overall cancer according to the prevalence and histological severity of NAFLD. NAFLD histological severity was defined in four categories: simple steatosis, NASH without fibrosis, noncirrhotic fibrosis, and cirrhosis. (For details, see Supporting Methods.) P values for the absolute incidence RDs for overall cancer between population comparators versus simple steatosis, NASH without fibrosis, noncirrhotic fibrosis, and cirrhosis were all <0.001. P values were approximated using the normal distribution. Abbreviations: NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; RDs, rate differences; ref., referent.