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. 2023 Jul 11;14:1229233. doi: 10.3389/fphar.2023.1229233

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Copyright © 2023 Qi, Chen, Wang, Yang, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of SRGs in genome and transcriptome. (A) The frequency of SRG mutations (Top 8) within TCGA-SARC cohort. (B) The CNV gain and loss of SRGs in TCGA-SARC cohort. (C) The chromosomal localization of SRGs within humans. (D) Analysis of co-occurring and mutually exclusive mutations in SRGs. (E) Principal component analysis (PCA) was conducted for differentiating STS from normal tissues on the basis of the expression patterns of SRGs. (F) Comparative analysis for expressing levels of SRGs in STS and normal tissues by utilizing the TCGA-GTEx database.