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. 2023 Jul 11;14:1229233. doi: 10.3389/fphar.2023.1229233

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Copyright © 2023 Qi, Chen, Wang, Yang, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genomic and transcriptional characteristics of senescence scoring model in TCGA-SARC cohort. (A,B) The top mutated genes among low and high senescence scoring cohorts. (C) Bar plots showing the GSVA for hallmark pathways between low and high senescence scoring cohorts. (D) The association between senescence score and predicted pathways for immunotherapy and cancer immunity cycles. (E) The frequencies of amplification and deletion at the arm level among the low and high senescence scoring cohorts. (F) Kaplan-Meier analysis was utilized to compare the low and high senescence score groups in the immunotherapy-treated cohort. (G) The proportion of clinical response among low and high senescence score groups treated with immunotherapy. (H) The drugs with significantly different estimated IC50 among low and high senescence scoring cohorts.