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. Author manuscript; available in PMC: 2023 Jul 25.
Published in final edited form as: ACS Chem Biol. 2022 Jun 24;17(7):1789–1798. doi: 10.1021/acschembio.2c00145

Figure 4: Effects of degradation vs inhibition on MOLM14 cell proliferation and viability.

Figure 4:

(A) Cells were seeded at a density of 0.5 × 105 cells/mL and treated with compounds every 3 days for 12 days. Significant reduction in cell proliferation by the PROTAC was observed between days 3 and 12. Proliferation was reduced by the epimer at day 6, however recovered to DMSO-treated levels by day 9. (B) MTS assay monitoring cell viability over 96 hours. The PROTAC is ~3x more potent than the epimer. Quantitation for A) and B) represents mean ± SD from three independent biological replicates performed in technical triplicate. Two-way ANOVA, Not significant (N.S.), * p < 0.05, **** p <0.0001.