Table 5.

Characteristics of bleeding events during pregnancy

Trimester	Anticoagulation at time of bleeding event		Severity of bleeding event (CTCAE* grade)		Treatment
First (n=10)	Aspirin	4	1	8	Observation/uterotonic	8
	Prophylactic heparin†	2	2	1	medications	1
	Therapeutic heparin†	3			Volume replacement/blood	1
	VKA‡	1			transfusion/factor complex
					Interventional treatment
Second (n=10) (APH n=8, PPH n=2)	Aspirin	4	1	6	Observation/uterotonic	5
	Therapeutic heparin†	1	3	2	medications	1
	VKA‡	2			Volume replacement/blood	3
	Combo§	3			transfusion/factor complex
					Interventional treatment
Third (n=18) (APH n=4, PPH n=14)	None	3	1	9	Observation/uterotonic	11
	Aspirin	5	2	5	medications	5
	Prophylactic heparin†	1	4	3	Volume replacement/blood	1
	Therapeutic heparin†	6			transfusion/factor complex	2
	VKA‡	1			Interventional treatment
	Combo§	1			surgery
Type of event
Antepartum haemorrhage (n=17)	Aspirin	6	1	11	Observation/uterotonic	11
	Prophylactic heparin†	3	2	3	medications	2
	Therapeutic heparin†	3	3	1	Volume replacement/blood	2
	VKA‡	3			transfusion/factor complex
	Combo§	2			Interventional treatment
Postpartum haemorrhage (n=16)	None	3	1	10	Observation/uterotonic	11
	Aspirin	5	2	3	medications	4
	Prophylactic heparin†	1	4	1	Volume replacement/blood	2
	Therapeutic heparin†	5			transfusion/factor complex
	VKA‡	1			Interventional treatment
	Combo§	1
Intracranial haemorrhage (n=1)	Combo§	1	III	1	Interventional treatment	1
Other (n=4)	Aspirin	2	I	2	Observation/uterotonic medications	2
	Therapeutic heparin†	2	IV	2	Unknown	2

^*NIH/NCI Common Terminology Criteria for Adverse Events.

^†Heparin here refers to either unfractionated heparin or low molecular weight heparin.

^‡Vitamin K antagonist.

^§Combination of anticoagulation/antiplatelet medications.

APH, antepartum haemorrhage; PPH, postpartum haemorrhage.