Table 6.

Patients with thrombotic complications

	Relevant diagnoses	Thrombosis risk factors	Details of thrombotic event	Treatment and outcome
Patient 1 Age 21 years	Pulmonary atresia+extracardiac Fontan	Prior arrhythmia Pre-pregnancy: ASA	At 6 weeks’ gestation, an asymptomatic intracardiac thrombus was incidentally noted (CTCAE grade II)	ASA and prophylactic LMWH. Delivered vaginally at 35 weeks after spontaneous preterm labour without complication
Patient 2 Age 22 years	Left atrial isomerism, severe LV dysfunction, moderate to severe AV valve regurgitation	LV dysfunction, prior VTE, cyanosis, saturations 88% Pre-pregnancy: ASA+oral AC	Hepatic vein thrombosis developed around delivery at 24 weeks’ gestation for umbilical artery flow reversal (CTCAE grade II)	1st TM: ASA+therapeutic LMWH 2nd TM/post partum—IV UFH – Infant passed away in perinatal period
Patient 3 Age 25 years	Tricuspid atresia+extracardiac Fontan	Mildly reduced ventricular function; chronic hypertension	3rd pregnancy, delivered via CS at 31 weeks due to PPROM. 24 hours later presented with CV collapse due to PE; CTCAE grade IV	AC throughout pregnancy: tinzaparin 12 000 IU/day Required ICU management for several days and returned to baseline

AC, anticoagulation; ASA, acetyls salicylic acid (aspirin); AV, atrioventricular; CS, caesarian section; CV, cardiovascular; ICU, intensive care unit; IV UFH, intravenous unfractionated heparin; LMWH, low molecular weight heparin; LV, left ventricular; PPROM, preterm premature rupture of membranes; TM, trimester; VTE, venous thrombo embolism.