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. 2023 Jul 12;27(7):1390–1399. doi: 10.1021/acs.oprd.3c00148

Table 4. Large-Scale Syntheses of 1 under Optimized Conditions (Step 2, Scheme 4).

entry scale (g) HPLC IPC (area % at 245 nm) isolated product
wt (g) HPLC (area % at 245 nm) purity (wt %) yield (%)
1 5 92.7 7.1 96.2 95.0 84
2 10 91.2 13.6 97.6 91.0 84
3 50 92.6 66.4 99.5 99.3 86
4 100 94.0 135 100 99.0 88