Table 1.
Group Demographic Characteristics
| NEG (n = 4) | LI (n = 11) | HI (n = 10) | p - value | |
|---|---|---|---|---|
|
| ||||
| Demographics | ||||
| Age, yr | 55.0 ± 15.0 | 51.5 ± 10.4 | 57.4 ± 9.3 | .458 |
| BMI, kg/m2 | 27.4 ± 2.5 | 31.0 ± 7.87 | 32.1 ± 7.9 | .569 |
| Hemodynamic variables | ||||
| mPAP, mmHg | 40.5 ± 10.4 | 48.9 ± 16.2 | 39.4 ±12.0 | .279 |
| RAP, mmHg | 6.0 ± 3.5 | 10.6 ± 5.0 | 6.7 ± 6.1 | .173 |
| PCWP, mmHg | 10.8 ± 3.1 | 11.1 ± 3.3 | 8.9 ± 3.3 | .289 |
| PVR, Wood units | 435.8 ± 150.8 | 678.4 ± 402.9 | 479.7 ± 212.5 | .252 |
| Qt, L/min | 5.5 ± 0.8 | 5.2 ± 1.7 | 5.6 ± 1.6 | .769 |
| Pulmonary function | ||||
| FVC, % predicted | 70.5 ± 14.5 | 62.7 ± 19.0 | 74.9 ± 13.4 | .261 |
| FEV1, % predicted | 70 ± 12.5 | 61.9 ± 16.5 | 70.9 ± 14.9 | .395 |
| FEV1/FVC, % | 80.5 ± 11.6 | 79.2 ± 8.0 | 77.8 ± 14.2 | .913 |
| DLCO, % predicted | 33.3 ± 9.6 | 49.6 ± 30.7 | 40.5 ± 15.0 | .469 |
| NYHA/WHO functional classification, % | ||||
| Class I | 0% | 9% | 0% | |
| Class II | 50% | 55% | 50% | |
| Class III | 50% | 27% | 50% | |
| Class IV | 0% | 9% | 0% | |
| Medications, % | ||||
| No medications | 0% | 9% | 0% | |
| Monotherapy | 25% | 27% | 40% | |
| Dual therapy | 75% | 9% | 30% | |
| Triple therapy | 0% | 45% | 30% | |
| Quadruple therapy | 0% | 9% | 0% | |
| Supplemental O2 | 75% | 64% | 50% | |
BMI = body mass index; mPAP = mean pulmonary arterial pressure; RAP = right atrial pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; FVC = forced vital capacity, FEV1 = forced expiratory volume in 1 second; FEV1/FVC = forced expiratory volume in 1 second to forced vital capacity ratio; DLCO = diffusion capacity of the lungs Values are expressed as mean ± SD unless otherwise specified p-values are for ANOVA between group main effects.