Table 2.
Baseline Cardiopulmonary Functional Characteristics
| NEG (n = 4) | LI (n = 11) | HI (n = 10) | p - value | |
|---|---|---|---|---|
|
| ||||
| 6MWD, m | 425.5 ± 96.8 | 407.4 ± 86.6 | 373.1 ± 86.1 | .529 |
| Peak VO2, ml/kg/min | 14.2 ± 2.2 | 16.2 ± 6.2 | 15.0 ± 6.6 | .823 |
| Peak WR, watts | 86.7 ± 34.1 | 110.5 ± 46.5 | 85.7 ± 37.2 | .354 |
| Time to fatigue, sec | 617.0 ± 186.5 | 693.0 ± 215.5 | 564.5 ± 166.6 | .328 |
| HR at peak, bpm | 138.2 ± 14.8 | 141.7 ± 14.8 | 137.7 ± 12.9 | .790 |
| SV at peak, ml | 94.0 ± 21.0a | 103.0 ± 23.9 | 95.0 ± 24.5b | .723 |
| Qt at peak, L/min | 13.1 ± 1.9a | 14.8 ± 4.4 | 13.4 ± 3.6b | .693 |
| a-vO2 Diff at peak | 8.3 ± 0.2a | 9.8 ± 6.8 | 8.6 ± 3.1b | .864 |
| VE peak, L/min | 40.4 ± 3.04 | 40.3 ± 11.0 | 48.6 ± 14.2 | .249 |
| VCO2 peak, L/min | 1045.6 ± 196.6 | 1168.9 ± 310.3 | 1194.1 ± 281.8 | .667 |
| VE/Qt peak | 3.1 ± 0.3 | 2.8 ± 0.6 | 3.4 ± 1.0 | .242 |
| VE/VO2 at peak | 39.0 ± 4.4 | 37.8 ± 15.2 | 43.0 ± 16.9 | .725 |
| VE/VCO2 at peak | 39.3 ± 6.2 | 35.3 ± 8.1 | 40.0 ± 8.8 | .295 |
| PETO2 at peak, mmHg | 147.9 ± 62.3 | 154.7 ± 55.1 | 153.8 ± 55.1 | .975 |
| PETCO2 at peak, mmHg | 32.9 ± 4.3 | 38.0 ± 9.0 | 32.4 ± 6.7 | .221 |
| Tidal Volume, ml | 1.2 ± 0.4 | 1.0 ± 0.3 | 1.2 ± 0,4 | .158 |
| Time at AT, sec | 262.8 ± 207.0 | 317.4 ± 144.7 | 204.1 ± 89.7 | .188 |
6MWD = six-minute walk distance; VO2 = oxygen consumption; WR = work rate; HR = heart rate; SV = stroke volume; Qt = cardiac output; QI = cardiac index; a-vO2 Diff = arteriovenous oxygen difference; VE = ventilation; VE/VO2 = ventilatory efficiency for O2; VE/VCO2 = ventilatory efficiency for CO2; PETO2 = expired end tidal O2; PETCO2 = expired end tidal CO2; AT = anaerobic threshold
p-values are for ANOVA between group main effects.
Values are expressed as mean ± SD
a
Due to equipment malfunction, n = 3
b
Due to equipment malfunction, n = 7