Table 2:
MACE and Heart failure event rates and Adjusted Risk difference and Hazard ratios for those without Cardiovascular disease for GLP1RA and SGLT2i vs DPP4i
| DPP4i | GLP1RA | DPP4i | SGLT2i | |
|---|---|---|---|---|
| N at risk in weighted cohort | 28,628 | 28,759 | 21,170 | 21,200 |
| N events primary outcome: | 482 | 359 | 233 | 186 |
| Composite Major Adverse Cardiovascular | ||||
| Events and Heart Failure Hospitalization | ||||
| Person-Years | 27082 | 26921 | 15590 | 14330 |
| Event Rate/1000 person-years (95% CI) | 17.8 (16.3, 19.4) | 13.3 (12.0, 14.8) | 14.9 (13.1, 17.0) | 12.9 (11.2, 14.9) |
| Adjusted Risk Difference (95% CI)† | 3.20 (1.12, 5.01) | 1.28 (−1.12, 3.32) | ||
| Weighted Unadjusted Hazard Ratio (95% CI) | Ref | 0.75 (0.67, 0.85) | Ref | 0.87 (0.74, 1.03) |
| Adjusted Hazard Ratio (95% CI)* | Ref | 0.82 (0.72, 0.94) | Ref | 0.91 (0.78, 1.08) |
| Secondary Outcomes | ||||
| N events cardiovascular hospitalization (Acute Myocardial Infarction, Stroke) | 189 | 140 | 99 | 89 |
| Person-Years | 27217 | 27025 | 15638 | 14358 |
| Event Rate/1000 person-years (95% CI) | 6.9 (6.0, 8.0) | 5.2 (4.4, 6.1) | 6.4 (5.2, 7.7) | 6.2 (5.0, 7.6) |
| Adjusted Risk Difference (95% CI) † | 0.93 (−0.47, 2.06) | .04 (−1.64, 1.36) | ||
| Weighted Unadjusted Hazard Ratio (95% CI) | Ref | 0.75 (0.62, 0.91) | Ref | 0.98 (0.77, 1.25) |
| Adjusted Hazard Ratio (95% CI)* | Ref | 0.87 (0.70, 1.07) | Ref | 0.99 (0.79, 1.26) |
| N events cardiovascular death | 121 | 79 | 61 | 48 |
| Person-Years | 27348 | 27113 | 15700 | 14400 |
| Event Rate/1000 person-years (95% CI) | 4.4 (3.7, 5.3) | 2.9 (2.3, 3.6) | 3.9 (3.0, 4.9) | 3.4 (2.5, 4.5) |
| Adjusted Risk Difference (95% CI) † | 1.29 (0.26, 2.07) | 0.10 (−1.31, 1.12) | ||
| Weighted Unadjusted Hazard Ratio (95% CI) | Ref | 0.66 (0.51, 0.85) | Ref | 0.88 (0.64, 1.22) |
| Adjusted Hazard Ratio (95% CI)* | Ref | 0.71 (0.53, 0.94) | Ref | 0.98 (0.71, 1.34) |
| N events heart failure hospitalization | 204 | 153 | 85 | 56 |
| Person-Years | 27207 | 27007 | 15650 | 14372 |
| Event Rate/1000 person-years (95% CI) | 7.5 (6.5, 8.6) | 5.7 (4.8, 6.6) | 5.4 (4.4, 6.7) | 3.9 (3.0, 5.0) |
| Adjusted Risk Difference (95% CI) † | 1.47 (0.11, 2.59) | 1.27 (−0.13, 2.32) | ||
| Weighted Unadjusted Hazard Ratio (95% CI) | Ref | 0.76 (0.63, 0.91) | Ref | 0.73 (0.54, 0.97) |
| Adjusted Hazard Ratio (95% CI)* | Ref | 0.80 (0.66, 0.99) | Ref | 0.77 (0.57, 1.02) |
| Preserved EF ≥50% | 25 events | 13 events | 10 events | 4 events |
| Event Rate/1000 person-years (95% CI) | 0.9 (0.6, 1.3) | 0.5 (0.3, 0.8) | 0.6 (0.3, 1.2) | 0.3 (0.1, 0.7) |
| Midrange EF 40-50% | 11 events | 7 events | 4 events | 1 event |
| Event Rate/1000 person-years (95% CI) | 0.4 (0.2, 0.7) | 0.3 (0.1, 0.5) | 0.3 (0.1, 0.7) | 0.1 (0.01, 0.4) |
| Reduced EF <40% | 13 events | 11 events | 6 events | 6 events |
| Event Rate/1000 person-years (95% CI) | 0.5 (0.3, 0.8) | 0.4 (0.2, 0.7) | 0.4 (0.2, 0.8) | 0.4 (0.2, 0.9) |
| Unknown EF | 155 events | 122 events | 65 events | 45 events |
| Event Rate/1000 person-years (95% CI) | 5.7 (4.9, 6.7) | 4.5 (3.8, 5.4) | 4.2 (3.3, 5.3) | 3.1 (2.3, 4.2) |
*
Fully adjusted model uses weighted cohort and adjust for all covariates listed in Table 1 All continuous variables were modeled as restricted cubic splines.
†
The adjusted rate difference is estimated by multiplying the unadjusted incident rate for DPP4i by the adjusted hazard ratio minus 1. Confidence bounds are calculated using the respective bounds from the hazard ratio