Table 2.

Key design feature comparison between countries

	Ethiopia	South Africa
Study population – index patients	Clinically diagnosed and bacteriologically confirmed pulmonary TB patients	Bacteriologically confirmed pulmonary TB patients
Study population – child contacts	Children < 15 years of age	Children < 5 years of Age
TPT regimena	3HP for those 3 2 years 3RH for those < 2 years 6H for those on ART	3RH for those 0-5 years 6H for those on ART
Community-based care model	Health extension worker based at health post in the community	Outreach team leader (professional nurse) teamed with community health worker
TPT initiation and follow-up	Performed by health extension worker; Task-shared with clinic TB focal person	Performed by professional nurse; Task-shifted from clinic TB focal nurse to a community-based health nurse
Persons responsible for TPT initiation and follow-up during trial	Utilized health system’s TB focal persons and health extension workers	Research nurse and clinic’s TB focal person
HIV testing	Not performed at household visits	Performed at household visits

^a3HP is 12 weekly doses of rifapentine and isoniazid; 3RH is 3 months of daily rifampicin and isoniazid; 6H is 6 months of daily isoniazid