Table 3.
Antibacterial duration and hospital/ICU LOS by AET and IET. DOT and LOS data are presented as mean ± standard deviation (interquartile range; median)
| Outcome | All positive cultures (N = 278,344 patients) |
P value | ABR-positive cultures (N = 93,252 patients) |
P value | MDR-positive cultures (N = 39,000 patients) |
P value | |||
|---|---|---|---|---|---|---|---|---|---|
| AET | IET | AET | IET | AET | IET | ||||
| Overall DOT |
6.79 ± 6.29 (3–8; 5) |
8.86 ± 9.03 (4–11; 6) |
< 0.001 |
8.10 ± 8.04 (4–10; 6) |
9.95 ± 10.36 (4–12; 7) |
< 0.001 |
9.89 ± 9.52 (4–12; 7) |
10.49 ± 10.80 (4–13; 7) |
< 0.001 |
| DOT by antibiotic | |||||||||
| ESC |
3.91 ± 3.86 (2–5; 3) |
4.33 ± 5.13 (2–5; 3) |
< 0.001 |
4.28 ± 4.81 (2–5; 3) |
4.48 ± 5.77 (2–5; 3) |
< 0.001 |
4.52 ± 6.22 (1–6; 3) |
4.49 ± 6.12 (2–5; 3) |
0.212 |
| Carbapenem |
5.04 ± 5.44 (2–6; 3) |
5.78 ± 6.77 (2–7; 4) |
< 0.001 |
5.70 ± 5.87 (2–7; 4) |
5.88 ± 6.82 (2–7; 4) |
< 0.001 |
6.07 ± 6.17 (3–7; 5) |
5.88 ± 7.04 (2–7; 4) |
0.423 |
| FQ |
3.25 ± 3.75 (1–4; 2) |
3.65 ± 4.89 (1–5; 2) |
< 0.001 |
3.72 ± 4.97 (1–5; 2) |
3.93 ± 5.41 (1–5; 2) |
< 0.001 |
4.10 ± 5.18 (1–5; 3) |
4.29 ± 6.15 (1–5; 3) |
0.007 |
| BLI combination |
4.06 ± 4.37 (2–5; 3) |
5.06 ± 6.19 (2–6; 3) |
< 0.001 |
4.42 ± 5.14 (2–6; 3) |
5.21 ± 6.60 (2–7; 3) |
< 0.001 |
4.57 ± 5.56 (2–6; 3) |
5.36 ± 6.86 (2–7; 3) |
< 0.001 |
| Glyco-peptides |
3.19 ± 4.09 (1–4; 2) |
4.05 ± 5.01 (1–5; 3) |
< 0.001 |
4.16 ± 5.63 (1–5; 3) |
4.48 ± 5.55 (1–6; 3) |
0.005 |
4.98 ± 6.52 (1–6; 3) |
4.74 ± 5.79 (1–6; 3) |
0.365 |
| Macrolides |
2.93 ± 3.61 (1–4; 2) |
3.59 ± 4.94 (2–4; 3) |
< 0.001 |
3.27 ± 4.48 (1–4; 3) |
3.93 ± 5.74 (1–4; 3) |
< 0.001 |
3.55 ± 5.62 (1–4; 3) |
4.18 ± 6.35 (1–5; 3) |
< 0.001 |
| LOS days |
9.04 ± 10.36 (4–10; 6) |
12.24 ± 15.28 (4–14; 7) |
< 0.001 |
10.72 ± 12.99 (4–12; 6) |
13.69 ± 17.62 (5–16; 8) |
< 0.001 |
13.06 ± 14.94 (5–15; 8) |
14.40 ± 17.83 (5–17; 9) |
< 0.001 |
| ICU LOS Days |
6.99 ± 8.77 (2–8; 4) |
9.39 ± 12.11 (2–12; 5) |
< 0.001 |
8.50 ± 10.95 (2–11; 4) |
10.62 ± 13.77 (2–14; 5) |
< 0.001 |
9.95 ± 12.24 (2–13; 5) |
11.00 ± 13.58 (3–14; 6) |
< 0.001 |
Definitions: AET = adequate empiric therapy; ABR = antibiotic resistant; DOT = days of therapy; ESC = extended-spectrum cephalosporins; FQ = fluoroquinolones; BLI = Beta-lactamase inhibitor; ICU = intensive care unit; IET = inadequate empiric therapy; LOS = length of stay; MDR = multidrug resistant