Table 1.
Clinical characteristics of HFrEF, HFmrEF, and HFpEF cohorts. Descriptive statistics of HFrEF, HFmrEF and HFpEF cohorts. F female, m male, BMI body mass index, BP blood pressure, LDL low-density lipoprotein, HDL high-density lipoprotein, ICD implantable cardioverter defibrillator, PCI percutaneous coronary intervention, NT-BNP N-terminal pro b-type natriuretic peptide. All numerical values are median (IQR), Elixhauser index is mean (SD)
| HF subtypes | |||||||
|---|---|---|---|---|---|---|---|
| Variable | N | Overall | HFpEF | HFmrEF | HFrEF | p-value* | p-value+ |
| (N = 17,665) | (N = 8062) | (N = 3018) | (N = 6585) | ||||
| Sex | 17,617 | < 0.001 | < 0.001 | ||||
| Female | 5247 (30%) | 2822 (35%) | 790 (26%) | 1635 (25%) | |||
| Male | 12,370 (70%) | 5228 (65%) | 2218 (74%) | 4924 (75%) | |||
| Age (years) | 17,665 | 70 (60, 78) | 70 (61, 78) | 70 (59, 77) | 70 (60, 78) | 0.093 | 0.5 |
| BMI | 9132 | 26.8 (24.2, 30.0) | 26.8 (24.2, 30.0) | 26.9 (24.2, 29,9) | 26.5 (24.1, 30.1) | 0.08 | 0.9 |
| Systolic BP (mmHg) | 5146 | 148 (134, 160) | 150 (139, 164) | 148 (135, 160) | 140 (127, 154) | < 0.001 | < 0.001 |
| Diastolic BP (mmHg) | 5146 | 84 (76, 92) | 85 (78, 93) | 84 (76, 93) | 82 (73, 90) | < 0.001 | < 0.001 |
| LDL (mg/dL) | 12,270 | 87 (69, 110) | 88 (69, 110) | 91 (72, 113) | 84 (67, 106) | < 0.001 | < 0.001 |
| HDL (mg/dL) | 12,368 | 44 (36, 54) | 46 (38, 56) | 43 (36, 53) | 40 (34, 50) | < 0.001 | < 0.001 |
| Triglycerides (mg/dL) | 13,859 | 112 (85, 153) | 112 (85, 151) | 112 (85, 156) | 113 (85, 156) | 0.11 | 0.006 |
| Cholesterol (mg/dL) | 13,577 | 160 (135, 188) | 163 (138, 190) | 164 (140, 192) | 153 (129, 183) | < 0.001 | < 0.001 |
| N PheCodes | 17,665 | 13 (8, 21) | 13 (9,21) | 12 (7, 19) | 14 (9, 22) | < 0.001 | 0.088 |
| Elixhauser Index | 17,665 | 5.39 (2.72) | 5.36 (2.68) | 5.09 (2.70) | 5.56 (2.76) | < 0.001 | < 0.001 |
| Intubated | 17,665 | 1766 (10.0%) | 552 (6.8) | 257 (8.5%) | 957 (15%) | < 0.001 | < 0.001 |
| ICD Implantation | 17,665 | 3213 (18%) | 1007 (12%) | 468 (16%) | 1738 (26%) | < 0.001 | < 0.001 |
| PCI | 17,665 | 9116 (52%) | 4267 (53%) | 1554 (51%) | 3295 (50%) | 0.002 | < 0.001 |
| log (NT-BNP) | 6169 | 2.99 (2.45, 3.53) | 3.07 (2.53, 3.55) | 3.07 (2.53, 3.55) | 3.45 (2.96, 3.88) | < 0.001 | < 0.001 |
All continuous values displayed as median (IQR) except for Elixhauser index which is mean (SD). All dichotomous values displayed as N (%)
*Kruskal–Wallis p-value across all subtypes
+Wilcoxon–rank sum or chi-squared p-value for HFpEF vs HFrEF