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. 2023 Jul 25;24:419. doi: 10.1186/s12864-023-09441-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The circRNA/lncRNA–miRNA–hub gene network and validation of the hub genes, miRNAs and circRNAs. (A) The circRNA/lncRNA–miRNA–hub gene network was constructed according to the ceRNA hypothesis and a subnetwork confirmed by qRT-PCR. Red and yellow represent up-regulation and blue means down-regulation. (B) GSE148219 and GSE76718 were used to validate the hub genes, and the intensity of differential expression is shown as a bar graph. (C) The relative expression of hub genes, miRNAs and circRNAs by qRT-PCR. Results are expressed as fold changes of control group