Table 1.
Baseline characteristics of individuals with ACH and controls (CPRD and CPRD HES-linked cohorts)
| Characteristic | CPRD | CPRD HES-linked | ||
|---|---|---|---|---|
| Cases (N = 541) n (%) | Controls (N = 2052) n (%) | Cases (N = 275) n (%) | Controls (N = 1064) n (%) | |
| Gender | ||||
| Male | 264 (49) | 1001 (49) | 136 (49) | 526 (49) |
| Female | 277 (51) | 1051 (51) | 139 (51) | 538 (51) |
| Location | ||||
| England | 366 (68) | 1394 (68) | 275 (100) | 1064 (100) |
| East of England | 62 (11) | 225 (11) | 48 (17) | 182 (17) |
| South Central | 50 (9) | 195 (10) | 36 (13) | 140 (13) |
| London | 50 (9) | 188 (9) | 35 (13) | 132 (12) |
| North West | 49 (9) | 190 (9) | 39 (14) | 152 (14) |
| South West | 40 (7) | 156 (8) | 36 (13) | 144 (14) |
| West Midlands | 40 (7) | 154 (8) | 24 (9) | 93 (9) |
| South East Coast | 33 (6) | 126 (6) | 27 (10) | 103 (10) |
| Yorkshire and The Humber | 16 (3) | 59 (3) | 12 (4) | 47 (4) |
| East Midlands | 14 (3) | 54 (3) | 8 (3) | 32 (3) |
| North East | 12 (2) | 47 (2) | 10 (4) | 39 (4) |
| Northern Ireland | 13 (2) | 50 (2) | – | – |
| Scotland | 87 (16) | 332 (16) | – | – |
| Wales | 75 (14) | 276 (13) | – | – |
| Age (years) | ||||
| Median (Q1–Q3) | 29 (9–43) | 29 (9–44) | 28 (7–40) | 28 (8–40) |
| 0–10 | 148 (27) | 558 (27) | 76 (28) | 293 (28) |
| 11–17 | 32 (6) | 120 (6) | 15 (5) | 58 (5) |
| 18–59 | 305 (56) | 1159 (56) | 163 (59) | 631 (59) |
| ≥ 60 | 56 (10) | 215 (10) | 21 (8) | 82 (8) |
| Follow-up | ||||
| Mean overall follow-up (years, SD) | 9.01 (6.89) | 11.74 (7.04) | 9.51 (7.17) | 11.76 (7.07) |
ACH Achondroplasia; CPRD Clinical Practice Research Database; HES Hospital Episode Statistics; N Total number of individuals; n number of individuals in subset; Q Quartile; SD Standard deviation