Fig. 5.

Effects of SE on the expression of insulin signaling proteins in skeletal muscle of db/db mice. The protein expression of (a) p-IRS/IRS ratio, (b) p-Akt/Akt ratio, and (c) GLUT4. All results were expressed following normalization with α-tubulin. The data were presented as mean ± SD. N + : db/m +  + saline; NC: db/db + saline; PC: db/db + metformin; SE200: db/db + stevia extract 200 mg/kg BW; SE500: db/db + stevia extract 500 mg/kg BW; SV: db/db + stevioside 40 mg/kg BW. ^### p < 0.001, ^## p < 0.01 vs. N + ; ^** p < 0.01, ^* p < 0.05 vs. NC