Fig. 6.

Effects of SE on the expression of mitochondrial activity proteins in skeletal muscle of db/db mice. The protein expression of (a) cytoplasmic p-AMPKα/AMPKα ratio, (b) cytoplasmic SIRT1, (c) nuclear SIRT1, (d) cytoplasmic PGC-1α, (e) nuclear PGC-1α, and (f) cytoplasmic CS. All results were expressed following normalization with α-tubulin or Lamin B1. The data were presented as mean ± SD. N + : db/m +  + saline; NC: db/db + saline; PC: db/db + metformin; SE200: db/db + stevia extract 200 mg/kg BW; SE500: db/db + stevia extract 500 mg/kg BW; SV: db/db + stevioside 40 mg/kg BW. ^### p < 0.001, ^## p < 0.01 vs. N + ; ^*** p < 0.001, ^** p < 0.01, ^* p < 0.05 vs. NC