Table 1.
Kasokero virus (KASV) infection and shedding dynamics in KASV-inoculated bats versus KASV + tick salivary gland extract (SGE)-inoculated bats
| Parameter | KASV-inoculated bats, arithmetic mean (SD)a | KASV + tick SGE-inoculated bats, arithmetic mean (SD)a | Statistical hypothesis testing |
|---|---|---|---|
| Duration of viremia (days) | 7.7 (1.9) | 6.9 (0.7) | Welch’s t-test, Welch-corrected t = 1.127, df = 7.572, P = 0.2941 |
| Peak viremia loads (log10TCID50eq/ml) | 5.4 (0.4)a | 4.9 (0.3)a | Mann-Whitney U = 7, P = 0.0262* |
| Cumulative viremia loads (log10TCID50eq/ml) | 5.8 (0.4)a | 5.2 (0.3)a | Unpaired t-test, t = 2.845, df = 12, P = 0.0148* |
| Duration of oral shedding (days) | 8.6 (1.9) | 7.3 (1.7) | Unpaired t-test, t = 1.332, df = 12, P = 0.2077 |
| Peak oral shedding loads (log10TCID50eq/ml) | 4.0 (1.0)a | 3.5 (1.1)a | Unpaired t-test, t = 0.7603, df = 12, P = 0.4617 |
| Cumulative oral shedding loads (log10TCID50eq/ml) | 4.2 (0.9)a | 3.8 (0.9)a | Unpaired t-test, t = 0.9088, df = 12, P = 0.3813 |
| Duration of rectal shedding (days) | 4.9 (2.5) | 2.6 (1.3) | Unpaired t-test, t = 2.571, df = 12, P = 0.0507 |
| Peak rectal shedding loads (log10TCID50eq/ml) | 3.0 (0.6)a | 2.1 (0.5)a | Unpaired t-test, t = 2.926, df = 12, P = 0.0127* |
| Cumulative rectal shedding loads (log10TCID50eq/ml) | 3.2 (0.6)a | 2.3 (0.5)a | Unpaired t-test, t = 3.299, df = 12, P = 0.0064* |
| Detection ratio in urine (detections/collections) | 0.48 (0.17) | 0.44 (0.12) | Unpaired t-test, t = 0.4967, df = 12, P = 0.6284 |
aIf KASV- and KASV + tick SGE-inoculated bat datasets were lognormally distributed, geometric means and geometric standard deviations were calculated, and statistical hypothesis testing was performed on log-transformed datasets; otherwise, arithmetic means and standard deviations were calculated, and no data transformations were performed prior to statistical hypothesis testing. SD: standard deviation, log10TCID50eq/ml: log10 50% tissue culture infectious dose equivalents per ml; t: test statistic, df: degrees of freedom, and P: probability