Table 1.

Description of qRT-PCR Genes

Symbol	Gene Name	RefSeq Number	Function
HIF1A	hypoxia inducible factor 1 subunit alpha	NM_001530	This gene encodes the α subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia
SOD2	superoxide dismutase 2	NM_000636	A member of the iron/manganese superoxide dismutase family, this gene encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen
VEGFA	Vascular endothelial growth factor A	NM_003376	A member of the PDGF/VEGF growth factor family, this gene encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis
HPRT1	Hypoxanthine phosphoribosyltransferase 1	NM_000194	Transferase which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. Critical to generation of purine nucleotides through the purine salvage pathway. Endogenous control for QPCR