Table 1.
Characteristics of the study participants by sex (n = 1,029)
| Characteristics | Total sample (n = 1,029) | Men (n = 417) | Women (n = 612) | P-value |
|---|---|---|---|---|
| Age range (years) | 60–88 | 60–84 | 60–88 | – |
| Age, years | 69.56 (4.47) | 69.69 (4.47) | 69.47 (4.48) | 0.472 |
| Education, n (%) | < 0.001 | |||
| Illiterate | 378 (36.73) | 40 (9.59) | 338 (55.23) | |
| Primary school | 446 (43.34) | 209 (50.12) | 237 (38.73) | |
| Middle school or above | 205 (19.92) | 168 (40.29) | 37 (6.05) | |
| Alcohol intake, n (%) | < 0.001 | |||
| Never | 632 (61.42) | 71 (17.03) | 561 (91.67) | |
| Former | 82 (7.97) | 75 (17.99) | 7 (1.14) | |
| Current | 315 (30.61) | 271 (64.99) | 44 (7.19) | |
| Smoking, n (%) | < 0.001 | |||
| Never | 681 (66.18) | 82 (19.66) | 599 (97.88) | |
| Former | 147 (14.29) | 140 (33.57) | 7 (1.14) | |
| Current | 201 (19.53) | 195 (46.76) | 6 (0.98) | |
| Obesity, n (%) | 214 (20.80) | 72 (17.27) | 142 (23.20) | 0.021 |
| APOE ε4 allele, n (%)a | 160 (15.55) | 64 (15.35) | 96 (15.69) | 0.758 |
| Stroke, n (%) | 133 (12.93) | 59 (14.15) | 74 (12.09) | 0.334 |
| Coronary heart disease, n (%) | 211 (20.51) | 60 (14.39) | 151 (24.67) | < 0.001 |
| Hypertension, n (%) | 731 (71.04) | 299 (71.70) | 432 (70.59) | 0.699 |
| Diabetes, n (%) | 158 (15.35) | 49 (11.75) | 109 (17.81) | 0.008 |
| Dyslipidemia, n (%) | 247 (24.00) | 66 (15.83) | 181 (29.58) | < 0.001 |
| Wear seasons, n (%) | 0.036 | |||
| Spring | 167 (16.23) | 68 (16.31) | 99 (16.18) | |
| Summer | 385 (37.41) | 153 (36.69) | 232 (37.91) | |
| Autumn | 398 (38.68) | 152 (36.45) | 246 (40.20) | |
| Winter | 79 (7.68) | 44 (10.55) | 35 (5.72) | |
| Daily ActiGraph wear time, hours | 14.17 (1.35) | 14.08 (1.38) | 14.23 (1.33) | 0.117 |
| Daily SB time, hours | 8.16 (1.92) | 8.84 (1.87) | 7.71 (1.81) | < 0.001 |
| Daily LPA time, hours | 4.93 (1.48) | 4.37 (1.47) | 5.32 (1.36) | < 0.001 |
| Daily MVPA time, hours | 1.08 (0.84) | 0.88 (0.69) | 1.21 (0.90) | < 0.001 |
| NfL, pg/ml, median (IQR) | 11.98 (6.60) | 12.99 (7.29) | 11.26 (6.20) | < 0.001 |
| IL-6, pg/ml, median (IQR) | 0.86 (0.68) | 0.86 (0.67) | 0.85 (0.67) | 0.584 |
| IL-8, pg/ml, median (IQR) | 17.30 (20.35) | 16.21 (17.40) | 18.39 (22.28) | 0.027 |
| TNF-α, pg/ml, median (IQR) | 1.73 (0.59) | 1.71 (0.58) | 1.74 (0.60) | 0.457 |
| ICAM-1, ng/ml, median (IQR) | 478.83 (100.52) | 466.93 (100.65) | 486.92 (99.71) | 0.002 |
Data were mean (SD), unless otherwise specified
Abbreviations: APOE Apolipoprotein E gene, SB Sedentary behavior, LPA Light-intensity physical activity, MVPA Moderate-to-vigorous-intensity physical activity, NfL Neurofilament light chain, IQR Interquartile range, IL-6 Interleukin-6, IL-8 Interleukin-8, TNF-α Tumor necrosis factor alpha, ICAM-1 Intercellular cell adhesion molecule-1
aThere were 13 participants who had missing information on APOE genotype and a dummy variable was created to represent these individuals in the subsequent analyses