Table 2.
Associations of accelerometer-assessed movement behaviors with plasma NfL concentration by daily sedentary behavior or physical activity time (n = 1,029)
| Behavioral factors | β-coefficient (95% confidence interval), plasma NfL (pg/ml), log-transformed | ||
|---|---|---|---|
| Model 1a | Model 2a | Model 3a | |
| Daily SB time, hours | |||
| < 8.00 (n = 478) | -0.008 (-0.043, 0.027) | -0.005 (-0.040, 0.030) | -0.041 (-0.086, 0.004) |
| ≥ 8.00 (n = 551) | 0.072 (0.037, 0.108)‡ | 0.060 (0.025, 0.095)† | 0.049 (0.005, 0.093)* |
| Daily LPA time, hours | |||
| < 5.00 (n = 530) | -0.112 (-0.158, -0.066)‡ | -0.091 (-0.137, -0.044)‡ | -0.073 (-0.123, -0.023)† |
| ≥ 5.00 (n = 499) | 0.027 (-0.020, 0.073) | 0.033 (-0.013, 0.079) | 0.038 (-0.008, 0.084) |
| Daily MVPA time, hours | |||
| < 2.00 (n = 902) | -0.123 (-0.183, -0.063)‡ | -0.119 (-0.179, -0.060)‡ | -0.108 (-0.175, -0.041)† |
| ≥ 2.00 (n = 127) | -0.067 (-0.184, 0.050) | -0.079 (-0.201, 0.042) | -0.087 (-0.210, 0.036) |
aModel 1 was adjusted for age, sex, education, wear seasons, and daily wear time of ActiGraph; Model 2 was additionally adjusted for smoking, alcohol intake, APOE ε4 allele, obesity, hypertension, dyslipidemia, diabetes, stroke, and coronary heart disease; and in Model 3, the analyses of MVPA and LPA were mutually adjusted for each other and the analyses of SB were adjusted for MVPA
Abbreviations: SB Sedentary behavior, LPA Light-intensity physical activity, MVPA Moderate-to-vigorous-intensity physical activity, NfL Neurofilament light chain
*P < 0.05, †P < 0.01, ‡P < 0.001