Table 3.
Associations of accelerometer-assessed movement behaviors with serum biomarkers of systemic low-grade inflammation (n = 991)
| Behavioral factors | β-coefficient (95% confidence interval), z scores of serum cytokines | ||
|---|---|---|---|
| Model 1# | Model 2# | Model 3# | |
| IL-6, z-score | |||
| Daily SB time, hours | 0.06 (0.03, 0.10)‡ | 0.06 (0.02, 0.09)† | 0.04 (-0.01, 0.10) |
| Daily LPA time, hours | -0.07 (-0.12, -0.02)† | -0.06 (-0.11, -0.01)* | -0.04 (-0.10, 0.01) |
| Daily MVPA time, hours | -0.13 (-0.21, -0.05)† | -0.10 (-0.18, -0.02)* | -0.08 (-0.16, 0.01) |
| IL-8, z-score | |||
| Daily SB time, hours | 0.05 (0.01, 0.09)* | 0.05 (0.01, 0.09)* | 0.05 (-0.01, 0.11) |
| Daily LPA time, hours | -0.06 (-0.12, -0.01)* | -0.06 (-0.12, -0.01)* | -0.05 (-0.11, 0.01) |
| Daily MVPA time, hours | -0.07 (-0.15, 0.02) | -0.08 (-0.16, -0.01) | -0.05 (-0.14, 0.04) |
| TNF-α, z-score | |||
| Daily SB time, hours | 0.06 (0.02, 0.09)† | 0.05 (0.01, 0.08)* | 0.03 (-0.02, 0.09) |
| Daily LPA time, hours | -0.07 (-0.11, -0.02)† | -0.05 (-0.10, 0.00)* | -0.03 (-0.09, 0.02) |
| Daily MVPA time, hours | -0.10 (-0.18, -0.02)* | -0.10 (-0.17, -0.02)* | -0.08 (-0.16, 0.01) |
| ICAM-1, z-score | |||
| Daily SB time, hours | 0.02 (-0.02, 0.06) | 0.01 (-0.02, 0.05) | 0.04 (-0.02, 0.10) |
| Daily LPA time, hours | -0.04 (-0.09, 0.01) | -0.03 (-0.08, 0.02) | -0.04 (-0.10, 0.02) |
| Daily MVPA time, hours | -0.01 (-0.09, 0.07) | 0.01 (-0.07, 0.09) | 0.04 (-0.05, 0.12) |
| Low-grade inflammation, composite score | |||
| Daily SB time, hours | 0.05 (0.02, 0.07)‡ | 0.04 (0.02, 0.07)† | 0.04 (0.01, 0.08)* |
| Daily LPA time, hours | -0.06 (-0.09, -0.03)‡ | -0.05 (-0.09, -0.02)† | -0.04 (-0.08, -0.01)* |
| Daily MVPA time, hours | -0.08 (-0.13, -0.03)† | -0.07 (-0.12, -0.01)* | -0.04 (-0.10, 0.02) |
#Model 1 was adjusted for age, sex, education, wear seasons, and daily wear time of ActiGraph; Model 2 was additionally adjusted for smoking, alcohol intake, APOE ε4 allele, obesity, hypertension, dyslipidemia, diabetes, stroke, and coronary heart disease; and in Model 3, the analyses of MVPA and LPA were mutually adjusted for each other and the analyses of SB were adjusted for MVPA
Abbreviations: SB Sedentary behavior, LPA Light physical activity, MVPA Moderate-to-vigorous intensity physical activity, IL-6 Interleukin-6, IL-8 Interleukin-8, TNF-α Tumor necrosis factor alpha, ICAM-1 Intercellular cell adhesion molecule-1
*P < 0.05, †P < 0.01, ‡P < 0.001