Table 4.
Mediation effect of low-grade inflammation on the association of movement behaviors with plasma NfL concentration (n = 991)
| Parameters from mediation models | Estimated β-coefficient (95% confidence interval) |
|---|---|
| Association of SB with plasma NfL | |
| Total effect | 0.033 (0.015, 0.052)‡ |
| Mediation effect by inflammation score | 0.005 (0.002, 0.010)‡ |
| Direct effect | 0.028 (0.010, 0.047)† |
| Proportion mediated | 0.161 (0.064, 0.396)‡ |
| Association of LPA with plasma NfL | |
| Total effect | -0.038 (-0.065, -0.014)† |
| Mediation effect by inflammation score | -0.007 (-0.013, -0.003)‡ |
| Direct effect | -0.031 (-0.057, -0.008)* |
| Proportion mediated | 0.178 (0.061, 0.484)† |
| Association of MVPA with plasma NfL | |
| Total effect | -0.061 (-0.097, -0.027)‡ |
| Mediation effect by inflammation score | -0.009 (-0.018, -0.003)† |
| Direct effect | -0.052 (-0.087, -0.016)† |
| Proportion mediated | 0.145 (0.041, 0.371)† |
Mediation analysis was adjusted for age, sex, education, and wear seasons and daily wear time of ActiGraph
Abbreviations: SB Sedentary behavior, LPA Light physical activity, MVPA Moderate-to-vigorous intensity physical activity, NfL Neurofilament light chain
*P < 0.05, †P < 0.01, ‡P < 0.001