Table 4.
Univariate and multivariate Cox proportional hazards analyses of risk factors for death in patients with MDA5+DM
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex, female | 0.45 (0.22–0.90) | 0.024 | 0.75 (0.31–1.78) | 0.512 |
| Age > 57 years old | 4.45 (2.17–9.15) | < 0.001 | 3.05 (1.20–7.80) | 0.020 |
| Ferritin > 1002.6 ng/mL | 3.54 (1.60–7.82) | 0.002 | 0.89 (0.29–2.76) | 0.837 |
| LDH > 388 U/L | 2.92 (1.46–5.85) | 0.002 | 1.29 (0.39–4.22) | 0.674 |
| ESR > 63 mm/h | 3.54 (1.72–7.28) | 0.001 | 1.78 (0.73–4.38) | 0.208 |
| Total lymphocyte count (/µL) | 1.00 (1.00–1.00) | 0.071 | – | – |
| CD3+T lymphocyte count (/µL) | 1.00 (1.00–1.00) | 0.021 | 1.00 (1.00–1.00) | 0.828 |
| CD8+T lymphocyte count (/µL) | 1.00 (0.99–1.00) | 0.023 | 1.00 (0.99–1.01) | 0.978 |
| Levels of anti-MDA5 antibody | 1.43 (0.75–2.71) | 0.277 | – | – |
| Levels of anti-Ro52 antibody | 1.70 (1.26–2.31) | 0.001 | 3.41 (1.36–8.53) | 0.009 |
| RP-ILD | 37.73 (11.34–125.6) | < 0.001 | 25.07 (5.42–115.98) | < 0.001 |
Bold text highlights the significance
“–” indicates not included in the multivariate model due to the lack of significant association in univariate analysis
MDA5+DM Anti-MDA5 dermatomyositis, LDH Lactate dehydrogenase, ESR Erythrocyte sedimentation rate, RP-ILD Rapidly progressive interstitial lung disease