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. 2023 Jul 25;16:171. doi: 10.1186/s12920-023-01602-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Liver tissue biopsy. a Unaccompanied interlobular bile ducts adjacent to arteries(Black arrow, 200 × , Hematoxylin and Eosin stain); (b) Obviously widening and fibrosis around the portal vein, accompanied by bile duct hyperplasia(Black arrow, 200 × , Hematoxylin and Eosin stain); (c, d) Inflammatory cell infiltration around portal vein: immunostaining of lymphocyte subtype CD3 + cells around portal vein(100 × , c);Immunostaining of lymphocyte subtype CD20 + cells around portal vein(100 × , d); (e) CK7 immunohistochemical staining showed the lack of interlobular bile ducts in the portal area, and slight bile duct hyperplasia at the edge of the portal area(White arrow, 100 ×); (f) Immunohistochemical staining showed positive expression of MDR3 protein beside hepatocytes (500 ×)