Table 2.

The GO and KEGG Enrichment Analysis of 10 pyroptosis-related differentially expressed genes in SONFH samples compared to non-SONFH samples

ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue
BP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	6/10	86/18670	1.66e-12	1.21e-09	4.06e-10
BP	GO:0050718	positive regulation of interleukin-1 beta secretion	5/10	33/18670	3.15e-12	1.21e-09	4.06e-10
BP	GO:0032611	interleukin-1 beta production	6/10	101/18670	4.45e-12	1.21e-09	4.06e-10
BP	GO:0050716	positive regulation of interleukin-1 secretion	5/10	38/18670	6.65e-12	1.36e-09	4.55e-10
BP	GO:0032612	interleukin-1 production	6/10	115/18670	9.85e-12	1.61e-09	5.39e-10
CC	GO:0061702	inflammasome complex	6/10	14/19717	7.72e-18	1.54e-16	6.50e-17
CC	GO:0044445	cytosolic part	6/10	247/19717	7.33e-10	7.33e-09	3.08e-09
CC	GO:0035578	azurophil granule lumen	2/10	91/19717	9.26e-04	0.006	0.003
CC	GO:0005766	primary lysosome	2/10	155/19717	0.003	0.011	0.004
CC	GO:0042582	azurophil granule	2/10	155/19717	0.003	0.011	0.004
MF	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	4/10	15/17697	7.00e-11	2.73e-09	1.18e-09
MF	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	3/10	16/17697	7.25e-08	9.42e-07	4.07e-07
MF	GO:0050700	CARD domain binding	3/10	16/17697	7.25e-08	9.42e-07	4.07e-07
MF	GO:0016505	peptidase activator activity involved in apoptotic process	3/10	19/17697	1.25e-07	1.22e-06	5.28e-07
MF	GO:0004197	cysteine-type endopeptidase activity	4/10	116/17697	3.57e-07	2.78e-06	1.20e-06
KEGG	hsa04621	NOD-like receptor signaling pathway	8/9	181/8076	4.82e-13	2.12e-11	1.32e-11
KEGG	hsa05132	Salmonella infection	6/9	249/8076	6.29e-08	1.38e-06	8.61e-07
KEGG	hsa05133	Pertussis	4/9	76/8076	8.81e-07	1.05e-05	6.54e-06
KEGG	hsa05130	Pathogenic Escherichia coli infection	5/9	197/8076	9.56e-07	1.05e-05	6.54e-06
KEGG	hsa05131	Shigellosis	5/9	246/8076	2.87e-06	2.28e-05	1.42e-05