Table 3.

Role of anti-CTLA-4/CTLA-4Ig in different autoimmune diseases.

Disease	Role of anti-CTLA4/CTLA-4Ig	References
Rheumatoid arthritis (RA)	Enhance Treg cell activity and reduce B-cell activity	(108, 173)
Systemic lupus erythematosus (SLE)	Inhibits to produce hyperactive T cells and promotes Treg cell induction	(119, 120)
Multiple sclerosis (MS)	Reduce the CD4+FoxP3+ Treg cell expression and CTLA-4 expression in the EAE mouse model	(130)
Type 1 diabetes (T1D)	Improve insulin sensitivity and macrophage differentiation and reduce proinflammatory cytokine production	(139)