| ADs | autoimmune diseases |
| CTLA-4 | cytotoxic T-lymphocyte antigen 4 |
| APCs | antigen-presenting cells |
| MHC | major histocompatibility complex |
| flCTLA-4 | full-length cytotoxic T-lymphocyte antigen 4 mRNA |
| sCTLA-4 | soluble cytotoxic T-lymphocyte antigen 4 |
| liCTLA-4 | ligand-independent cytotoxic T-lymphocyte antigen 4 |
| NF-AT | nuclear factor of activated T cells |
| cAMP | cyclic adenosine monophosphate |
| TGN | trans-Golgi network |
| GTPases | guanosine triphosphatases |
| ARF-1 | adenosine diphosphate ribosylation factor-1 |
| PLD | phospholipase D |
| CAP-1 | clathrin adaptor protein-1 |
| CAP-2 | clathrin adaptor protein-2 |
| IL-2 | interleukin 2 |
| TCR | T-cell antigen receptor |
| Bcl-Xl | apoptosis regulator Bcl-X |
| LAT | linker for activation of T cells |
| NF-κB | transcription factor nuclear factor B |
| Treg | regulatory T cell |
| DCs | dendritic cells |
| GRB2 | growth factor receptor bound protein |
| SOS | Son-of-Sevenless |
| SYP | tyrosine phosphatase synaptophysin |
| CXCR4 | C-X-C chemokine receptor type 4 |
| PIP3 | phosphatidylinositol (3 |
| 4 | 5)-trisphosphates |
| PH | pleckstrin homology |
| PDK1 | PH domain kinase 1 |
| mTORC2 | rapamycin complex 2 |
| PP2A | serine/threonine phosphatase PP2A |
| SHIP2 | tyrosine phosphatase SHIP2 |
| BAD | BL2-associated agonist of cell death |
| cdCTLA 4 | cytoplasmic domain of CTLA-4 |
| Tfr | follicular regulatory T |
| Tfh | follicular helper T |
| GC | germinal center |
| RA | rheumatoid arthritis |
| RF | rheumatic factor |
| ACPA | anti-citrullinated protein antibodies |
| Treg | regulatory T cell |
| Tcon | conventional T |
| IDO | indoleamine 2, 3-dioxygenase |
| SLE | lupus erythematosus |
| MS | multiple sclerosis |
| CNS | central nervous system |
| IFN-γ | interferon-γ |
| AP- | cell-penetrating peptide (AP)-conjugated |
| ctCTLA-4 | CTLA-4 cytoplasmic domain |
| T1D | type 1 diabetes |
| NOD | non-obese diabetes |
| CRP | C-reactive protein |
| AITD | autoimmune thyroid disease |
| HT | Hashimoto's thyroiditis |
| EHT | experimental Hashimoto's thyroiditis |
| MG | myasthenia gravis |
| NMJ | neuromuscular junction |
| AChR | acetylcholine receptor |
| MuSK | muscle-specific kinase |
| AChR | anti-acetylcholine receptor |
| CTLA-4Ig | CTLA-4 immunoglobulin |