ADs |
autoimmune diseases |
CTLA-4 |
cytotoxic T-lymphocyte antigen 4 |
APCs |
antigen-presenting cells |
MHC |
major histocompatibility complex |
flCTLA-4 |
full-length cytotoxic T-lymphocyte antigen 4 mRNA |
sCTLA-4 |
soluble cytotoxic T-lymphocyte antigen 4 |
liCTLA-4 |
ligand-independent cytotoxic T-lymphocyte antigen 4 |
NF-AT |
nuclear factor of activated T cells |
cAMP |
cyclic adenosine monophosphate |
TGN |
trans-Golgi network |
GTPases |
guanosine triphosphatases |
ARF-1 |
adenosine diphosphate ribosylation factor-1 |
PLD |
phospholipase D |
CAP-1 |
clathrin adaptor protein-1 |
CAP-2 |
clathrin adaptor protein-2 |
IL-2 |
interleukin 2 |
TCR |
T-cell antigen receptor |
Bcl-Xl |
apoptosis regulator Bcl-X |
LAT |
linker for activation of T cells |
NF-κB |
transcription factor nuclear factor B |
Treg |
regulatory T cell |
DCs |
dendritic cells |
GRB2 |
growth factor receptor bound protein |
SOS |
Son-of-Sevenless |
SYP |
tyrosine phosphatase synaptophysin |
CXCR4 |
C-X-C chemokine receptor type 4 |
PIP3 |
phosphatidylinositol (3 |
4 |
5)-trisphosphates |
PH |
pleckstrin homology |
PDK1 |
PH domain kinase 1 |
mTORC2 |
rapamycin complex 2 |
PP2A |
serine/threonine phosphatase PP2A |
SHIP2 |
tyrosine phosphatase SHIP2 |
BAD |
BL2-associated agonist of cell death |
cdCTLA 4 |
cytoplasmic domain of CTLA-4 |
Tfr |
follicular regulatory T |
Tfh |
follicular helper T |
GC |
germinal center |
RA |
rheumatoid arthritis |
RF |
rheumatic factor |
ACPA |
anti-citrullinated protein antibodies |
Treg |
regulatory T cell |
Tcon |
conventional T |
IDO |
indoleamine 2, 3-dioxygenase |
SLE |
lupus erythematosus |
MS |
multiple sclerosis |
CNS |
central nervous system |
IFN-γ |
interferon-γ |
AP- |
cell-penetrating peptide (AP)-conjugated |
ctCTLA-4 |
CTLA-4 cytoplasmic domain |
T1D |
type 1 diabetes |
NOD |
non-obese diabetes |
CRP |
C-reactive protein |
AITD |
autoimmune thyroid disease |
HT |
Hashimoto's thyroiditis |
EHT |
experimental Hashimoto's thyroiditis |
MG |
myasthenia gravis |
NMJ |
neuromuscular junction |
AChR |
acetylcholine receptor |
MuSK |
muscle-specific kinase |
AChR |
anti-acetylcholine receptor |
CTLA-4Ig |
CTLA-4 immunoglobulin |