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. 2023 Jul 11;14:1198365. doi: 10.3389/fimmu.2023.1198365
ADs autoimmune diseases
CTLA-4 cytotoxic T-lymphocyte antigen 4
APCs antigen-presenting cells
MHC major histocompatibility complex
flCTLA-4 full-length cytotoxic T-lymphocyte antigen 4 mRNA
sCTLA-4 soluble cytotoxic T-lymphocyte antigen 4
liCTLA-4 ligand-independent cytotoxic T-lymphocyte antigen 4
NF-AT nuclear factor of activated T cells
cAMP cyclic adenosine monophosphate
TGN trans-Golgi network
GTPases guanosine triphosphatases
ARF-1 adenosine diphosphate ribosylation factor-1
PLD phospholipase D
CAP-1 clathrin adaptor protein-1
CAP-2 clathrin adaptor protein-2
IL-2 interleukin 2
TCR T-cell antigen receptor
Bcl-Xl apoptosis regulator Bcl-X
LAT linker for activation of T cells
NF-κB transcription factor nuclear factor B
Treg regulatory T cell
DCs dendritic cells
GRB2 growth factor receptor bound protein
SOS Son-of-Sevenless
SYP tyrosine phosphatase synaptophysin
CXCR4 C-X-C chemokine receptor type 4
PIP3 phosphatidylinositol (3
4 5)-trisphosphates
PH pleckstrin homology
PDK1 PH domain kinase 1
mTORC2 rapamycin complex 2
PP2A serine/threonine phosphatase PP2A
SHIP2 tyrosine phosphatase SHIP2
BAD BL2-associated agonist of cell death
cdCTLA 4 cytoplasmic domain of CTLA-4
Tfr follicular regulatory T
Tfh follicular helper T
GC germinal center
RA rheumatoid arthritis
RF rheumatic factor
ACPA anti-citrullinated protein antibodies
Treg regulatory T cell
Tcon conventional T
IDO indoleamine 2, 3-dioxygenase
SLE lupus erythematosus
MS multiple sclerosis
CNS central nervous system
IFN-γ interferon-γ
AP- cell-penetrating peptide (AP)-conjugated
ctCTLA-4 CTLA-4 cytoplasmic domain
T1D type 1 diabetes
NOD non-obese diabetes
CRP C-reactive protein
AITD autoimmune thyroid disease
HT Hashimoto's thyroiditis
EHT experimental Hashimoto's thyroiditis
MG myasthenia gravis
NMJ neuromuscular junction
AChR acetylcholine receptor
MuSK muscle-specific kinase
AChR anti-acetylcholine receptor
CTLA-4Ig CTLA-4 immunoglobulin