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. 2023 Jul 11;14:1210943. doi: 10.3389/fendo.2023.1210943

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Copyright © 2023 Missaoui, Hamza, Belabed, Mellouli, Maaloul, Charfi, Jardak, Sellami-Boudawara, Rekik and Abid

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological analysis of a bifocal mixed presentation of papillary thyroid carcinoma with classic and warthin-like histology in our reported patient. Nodule A: Warthin-like papillary thyroid carcinoma (A1-A4). (A1) Histological examination revealed the presence of branching papillae composed of oncocytic tumor cells amidst a reactive lymphoid stroma (yellow star) (HEx50). (A2) A prominent lymphoplasmacytic infiltrate was identified within the cores of the papillae (→) (HEx100). (A3) The tumor cells exhibited nuclear enlargement, chromatin clearing, and nuclear groove (→) (HEx400). (A4) Pseudoinclusions were observed in the nuclei of the tumor cells (→) (HEx400). Nodule B: Classic papillary thyroid carcinoma (B1-B4). (B1) Classic papillary thyroid carcinoma (black star) was identified invading the thyroid parenchyma (blue star) (HEx50). (B2) The tumor featured a proliferation of complex papillae (HEx100). (B3) The cores of the papillae were identified as fibrovascular without a background of reactive lymphoid stroma (HEx200). (B4) The tumor cells exhibited distinctive papillary nuclear features such as nuclear enlargement and chromatin clearing (→) (HEx400).