Figure 4.

RNA m⁶A modification in the regulation of ferroptosis. A. Schematic representation of RNA m⁶A modification. RNA m⁶A marks are deposited by “writers”, and methyltransferase-like 3 (METTL3), METTL14, and METTL16 are the major methyltransferases. In contrast, an RNA m⁶A methyl group is removed by “erasers”, such as fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5). m⁶A-modified RNA is recognized by “readers”, which determine the fate of the RNA, such as degradation, translation, alternative splicing, pri-miRNA processing, or nuclear export. B. The RNA m⁶A modification contributes to ferroptosis regulation by affecting the stability of mRNAs or their alternative splicing.