. 2023 Jul 3;19(11):3472–3482. doi: 10.7150/ijbs.84353

Table 1.

The pain model, expression, localization of the IGF/IGF-1R aggravating the pain.

IGF/IGF-1R	Pain model	Expression	Localization	Reference
IGF/IGF-1R	DRG neuron/CFA	DRG ↑	Neuron	70
IGF-1R	CFA	DRG -	Neuron	71
IGF-1/IGF-1R	bone cancer pain.	tibia bone cavity ↑	Neuron	73
IGF-1	lumbar disc herniation (LDH) model	DRG ↑	Neuron	⁵⁸ ⁷⁴
IGF-1	infraorbital nerve injury (IONI) induced neuropathic pain	TG ↑ infraorbital nerve ↑	Macrophage Satellite glial cell	76
IGF-1/IGF-1R	Spinal cord injury induced neuropathic pain	-	-	-
IGF-1/IGF-1R	pain associated with endometriosis	peritoneal fluid (PF) ↑	Macrophage (IBA1)	77
IGF-1/IGF-1R	TG neuron	TG	Neuron	73
IGF-1/IGF-1R	chronic constriction injury (CCI)	Spinal cord ↑	Microglia (IGF-1) Astrocyte (IGF-1) Neuron (IGF-1) Neuron (IGF-1R)	78
IGF-1/ IGF-1R	plantar incision induced pain	DRG ↑	Neuron (IGF-1R) Satellite glial cell (IGF-1R)	34
IGF-1/IGF-1R	Intraplantar recombinant (r) IGF-1	DRG (IGF-1R) ↑	TRPV1 neuron	67
IGF-2	spared nerve injury (SNI) induced neuropathic pain	Spinal cord ↑	Neuron CD11b microglia	⁷⁹ ⁸⁰