Table 2.
The pain model, expression, localization of the IGF/IGF-1R relieving the pain.
| IGF/IGF-1R | Pain model | Expression | Localization | Reference |
|---|---|---|---|---|
| IGF-1/ IGF-1R | plantar incision induced pain | Plantar tissue ↑ | DRG | 69 |
| IGF-1 | spinal nerve injury model | Spinal cord ↑ | CD11c+ microglia | 35 |
| IGF-1/IGF-1R | Chemotherapy-induced peripheral neuropathy (CIPN) | spinal cord↓ spinal cord neuron activity - |
IGF-1 (astrocyte) IGF-1R (Neuron) - |
82
83 |
| IGF-1 | Diabetic peripheral neuropathy (DPN) induced neuropathic pain | Serum ↓ spinal cord ↓ |
- astrocyte Neuron microglia (major) |
85
87 |
| IGF-1 | spinal cord compression injury (SCI) induced neuropathic pain | DRG - | - | 86 |
| IGF-1 | neuropathic pain following deafferentation injury | DRG - | - | 88 |