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Expression of CREG1 was decreased in megakaryocytes of mice treated with cytosine arabinoside. (A) Mice treated intraperitoneally with Ara-c. (B) PLT count in the peripheral blood. (C) Expression of Creg1 mRNA by real-time PCR after treatment with cytosine arabinoside for 5 and 10 days. (D) CREG1 protein was analyzed by western blot in megakaryocytes. Values are means ± SEM. n=20 mice/group. **P < 0.01 versus control, ##P < 0.01 versus Day 5. Ara-c: cytosine arabinoside.
