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. 2023 Jul 9;19(11):3614–3627. doi: 10.7150/ijbs.78660

Figure 3.

Figure 3

Lack of CREG1 led to reduced platelet production. (A-C) PLT, RBC, and WBC counts in the peripheral blood. (D) MPV; (n=15). (E) Transmission electron microscopy (TEM) analysis of platelets; (n=5). (F) Platelet survival was measured after intravenous injection of DyLight™ 488-conjugated anti-GPIbβ Ig derivative (0.1 µg/g body weight) in the tail vein. (G) Platelets were first eliminated by intravenous injection of anti-CD42b (2 mg/g) in the tail vein. (H) Western blot was used to analyze cleaved caspase-3 expression in platelets. (I) Apoptotic platelets were detected by annexin V staining using flow cytometry; (n=3). Values are means ± SEM. **P < 0.01 versus Creg1fl/fl. MPV: mean platelet volume.