Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 9;19(11):3614–3627. doi: 10.7150/ijbs.78660

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Silencing of CREG1 altered the morphology and caused low-ploidy developmental delay of megakaryocytes. (A-B) The volume and cytoplasm of Dami cells decreased by CREG1 knockdown, and the percentage of cells with diameters > 20 μm in three randomly selected fields was calculated. (C) Wright-Giemsa staining confirmed that knockdown of CREG1 inhibited Dami cell differentiation and decreased the cytoplasmic volume and DNA ploidy. (D-E) Polyploidy analyzed by flow cytometry. Values are means ± SEM, n=3. *P < 0.05, **P < 0.01 versus siScramble; ^#P < 0.05, ^##P < 0.01 versus siScramble + PMA 4 d.