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. 2023 Jul 9;19(11):3614–3627. doi: 10.7150/ijbs.78660

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Alteration of the ERK1/2 and PAK/LIMK1/Cofilin phosphorylation signaling pathways in Creg1^pf4-cre megakaryocytes. (A-B) Expression of CREG1, p-MEK1/2, and p-ERK1/2 was assayed by western blot in Creg1^pf4-cre megakaryocytes. (C) Immunofluorescence staining of MEK1/2 and CREG1 in Creg1^fl/fl megakaryocytes. (D) Co-immunoprecipitation of MEK1 and CREG1 in Creg1^fl/fl megakaryocytes. (E-F) Expression of p-PAK1, p-LIMK1, and p-Cofilin1 was determined by western blot in Creg1^pf4-cre megakaryocytes. Values are means ± SEM, n=3. **P < 0.01 versus Creg1^fl/fl.